The impact of weight gain on antipsychotic nonadherence or discontinuation: A systematic review and meta-analysis.

ABSTRACT:

Background

Nonadherence/discontinuation of antipsychotic (AP) medications represents an important clinical issue in patients across psychiatric disorders, including schizophrenia spectrum disorders (SSDs). While antipsychotic-induced weight gain (AIWG) is a reported contributor to nonadherence, a systematic review of the association between AIWG and medication nonadherence/discontinuation has not been explored previously.

Method

A systematic search was conducted in MEDLINE, EMBASE, PsychINFO, CINAHL, and CENTRAL databases, among others, to help identify all studies which explored adherence, study dropouts, AP switching and/or discontinuations attributable to AIWG among individuals with severe mental illness. A meta-analysis was also completed where applicable.

Results

SUBMITTER: De R 

PROVIDER: S-EPMC11695092 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature