Risk and timing of postpartum depression in parents of twins compared to parents of singletons.

ABSTRACT:

Background

Parents of twins appear to be at increased risk of postpartum depression (PPD), yet little is known about the magnitude and timing of onset in the postpartum period compared to singleton parents.

Methods

We conducted a cohort study using the Danish nationwide health registers. We defined a study population of parents that is, mothers and fathers of all twin and singleton livebirths between 1997 and 2019. Postpartum depression was defined as incident depression diagnosis or a redeemed antidepressant prescription from childbirth through 365 days postpartum. We performed a parametric time-to-event analysis based on Poisson regression. The time scale was time since birth, modeled using restricted cubic splines. From this we estimated the hazard ratio (HR) representing

SUBMITTER: Egsgaard S 

PROVIDER: S-EPMC11695093 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature