PhoR1-PhoP1, a third two-component system of the family PhoRP from Myxococcus xanthus: role in development.

ABSTRACT: The pair PhoR1-PhoP1 is the third two-component system of the family PhoRP reported in M. xanthus. PhoR1 is a histidine kinase anchored to the membrane through a transmembrane domain located in the amino-terminal portion of the protein. As a result, 93% of the protein is located in the cytoplasm. This topology is unusual in the PhoR-type histidine kinases. PhoP1 is a response regulator with a helix-loop-helix motif typical of the DNA-binding proteins. Although the operon phoPR1 is expressed during vegetative growth, it peaks during development. The expression levels of this operon are higher in phosphate-containing media than in those in which the nutrient is absent. A deletion mutant in this system exhibits a delay in aggregation and the formation of fruiting bodies larger than those of t

SUBMITTER: Carrero-Lerida J 

PROVIDER: S-EPMC1169532 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature