Genetic Influence of the Brain on Muscle Structure: A Mendelian Randomization Study of Sarcopenia.

ABSTRACT:

Background

The association between brain and sarcopenia has not been clarified. We aim to investigate the causal association between brain structure, function, gene expression and sarcopenia-related traits.

Methods

All participants were Europeans. GWAS data of Brain Imaging Data Structure (BIDs) was from the UK Biobank. Gene expression in 13 brain regions was acquired from the GTEx Consortium. The sarcopenia-related traits, including appendicular lean mass (ALM), whole body lean mass (WBLM), grip strength and sarcopenia diagnosed by the European Working Group on Sarcopenia in Older People (EWGSOP) or Foundation for the National Institutes of Health (FNIH), were from the IEU website. The inverse variance weighted (IVW), MR Egger, weighted median, weighted mode and Wald ratio

SUBMITTER: Lei T 

PROVIDER: S-EPMC11695463 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature