Semi-standardized evaluation of extraprostatic extension and seminal vesicle invasion with [¹⁸F]PSMA-1007 PET/CT: a comparison to MRI using histopathology as reference.

ABSTRACT:

Background

Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity in methods and results. Our aim was to compare [¹⁸F]PSMA-1007 PET/CT to magnetic resonance imaging (MRI) in evaluation of EPE and SVI, building on a previously described method for standardized evaluation. We retrospectively included 124 patients who had undergone MRI, PSMA PET/CT and prostatectomy. PSMA PET/CT images were evaluated by two nuclear medicine physicians. Using a stan

SUBMITTER: Hvittfeldt E 

PROVIDER: S-EPMC11695508 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature