Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation.

ABSTRACT: Bone remodeling maintains the robustness of the bone tissue by balancing bone resorption by osteoclasts and bone formation by osteoblasts. Although these cells together play a crucial role in bone remodeling, only a few reports are available on the common factors involved in the differentiation of the two types of cells. Here, we show family with sequence similarity 102 member A (Fam102a) as a bone-remodeling factor that positively regulates both osteoclast and osteoblast differentiation. Fam102a regulates osteoblast differentiation by controlling recombination signal binding protein for immunoglobulin κ J region-like (Rbpjl). The Fam102a-Rbpjl axis promotes the nuclear translocation of transcription factors and enhances the expression of Osterix, a transcription factor essential for osteo

SUBMITTER: Yamashita Y 

PROVIDER: S-EPMC11695619 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature