Molecular characterization of gliosarcoma reveals prognostic biomarkers and clinical parallels with glioblastoma.

ABSTRACT:

Purpose

Gliosarcoma is a rare histopathological variant of glioblastoma, but it is unclear whether distinct clinical or molecular features distinguish it from other glioblastomas. The purpose of this study was to characterize common genomic alterations of gliosarcoma, compare them to that of glioblastoma, and correlate them with prognosis.

Methods

This was a single-institution, retrospective cohort study of patients seen between 11/1/2017 to 1/28/2024. Clinical and genomic data were obtained from the medical record. Results were validated using data from AACR Project GENIE (v15.1-public).

Results

We identified 87 gliosarcoma patients in the institutional cohort. Compared to a contemporary cohort of 492 glioblastoma, there was no difference in overall survival, though

SUBMITTER: Chen L 

PROVIDER: S-EPMC11695672 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature