Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia.

ABSTRACT: Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium tuberculosis (Mtb) without adaptive immunity. In heavily exposed Indonesian tuberculosis household contacts (n = 1347), a persistently IGRA negative status was associated with presence of a BCG scar, and - especially among those with a BCG scar - with altered innate immune cells dynamics, higher heterologous (Escherichia coli-induced) proinflammatory cytokine production, and higher inflammatory proteins in the IGRA mitogen tube. Neither circulating concentrations of Mtb-specific ant

SUBMITTER: Setiabudiawan TP 

PROVIDER: S-EPMC11695729 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature