Evaluation of ovarian stiffness and its biological mechanism using shear wave elastography in polycystic ovary syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with various contributing factors. Shear wave elastography (SWE) is a contemporary noninvasive imaging technique that reports on the elasticity of tissues. This study aimed to evaluate ovarian stiffness in patients with PCOS using transvaginal SWE, and investigate the potential biological mechanisms underlying increased ovarian stiffness. Patients with PCOS and healthy controls underwent transvaginal 2D ultrasound and SWE to measure the number of follicles, ovarian volume, and ovarian elasticity. Multivariate logistic regression analysis was conducted to identify risk factors for PCOS. A rat model of PCOS was established to further investigate the biological basis of increased ovarian stiffness. Histological analysis, enzyme-l

SUBMITTER: He Y 

PROVIDER: S-EPMC11695736 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature