Development and preliminary validation of five miRNAs for lung adenocarcinoma prognostic model associated with immune infiltration.

ABSTRACT: Our aim was to investigate the potential value of immune-related miRNA signaling in predicting clinical prognosis and immunotherapy. We first identified immune-related miRNAs in lung adenocarcinoma (LUAD), and then constructed a miRNA-based risk model by lasso regression modeling. Finally, we validated our findings using RT-qPCR in serum from LUAD patients and normal patients. Weighted gene co-expression network analysis (WGCNA) was used to screen the aberrantly expressed genes associated with immune scores, and then correlation analysis and prognostic analysis were used to identify and immune-associated miRNAs, and lasso-cox regression was used to construct an immune-associated 5-miRNA model. Risk score as an independent prognostic factor could accurately predict the prognosis of LUAD pat

SUBMITTER: Yang H 

PROVIDER: S-EPMC11695782 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature