Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score.

ABSTRACT:

Background and aims

Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).

Methods

Proenkephalin was measured in plasma in a prospective multicentre ACS cohort from Switzerland (n = 4787) and in validation cohorts from the UK (n = 1141), Czechia (n = 927), and Germany (n = 220). A biomarker-enhanced risk score (KID-ACS score) for simultaneous prediction of in-hospital acute kidney injury (AKI) and 30-day mortality was derived and externally validated.

Results

On multivariable adjustment for established risk factors, circulating PENK remained associated with in-hos

SUBMITTER: Wenzl FA 

PROVIDER: S-EPMC11695896 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature