Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes.

ABSTRACT: The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network by selective activation of microtubule-regulating proteins, including microtubule-severing enzymes, has emerged as a central process in neuronal wiring. Tubulin posttranslational modifications control both microtubule properties and the activities of their interacting proteins. However, whether and how tubulin posttranslational modifications may contribute to neuronal connectivity has not yet been addressed. Here we show that the microtubule-severing proteins p60-katanin and spastin play specific roles in axon guidance during zebrafish embryogenesis and identify a key role for tubulin polyglutamylation in their functional specificity. Furthermore, our work reveals t

SUBMITTER: Ten Martin D 

PROVIDER: S-EPMC11695996 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature