Wearable electrodriven switch actively delivers macromolecular drugs to fundus in non-invasive and controllable manners.

ABSTRACT: Current treatments for fundus disorders, such as intravitreal injections, pose risks, including infection and retinal detachment, and are limited in their ability to deliver macromolecular drugs across the blood‒retinal barrier. Although non-invasive methods are safer, their delivery efficiency remains suboptimal (<5%). We have developed a wearable electrodriven switch (WES) that improves the non-invasive delivery of macromolecules to the fundus. The WES system, which integrates an electrodriven drug delivery lens with a square wave generator, leverages electrical stimulation to enhance drug penetration through the sclera-choroid-retina pathway. In our study, WES achieved a delivery efficiency of 14% for immunoglobulin G, comparable to that of intravitreal injection (16%). Moreover, WES-en

SUBMITTER: Qin X 

PROVIDER: S-EPMC11695998 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature