Analysis of precancerous lesion-related microRNAs for early diagnosis of cervical cancer in the Thai population.

ABSTRACT: The incidence rate of cervical cancer (CC) is three times greater in Southeast Asia (SEA), where screening tests are less common than in Northern America, underlining a need for convenient self-diagnostic methods. The expression pattern of microRNAs (miRNAs) has been considered a molecular tool for non-invasive cancer diagnosis and prognosis. This study aimed at the development of the first miRNA biomarker panel for early detection of CC in Thai women. Genome-wide miRNA expression profiling was performed on cervical tissue and discharge samples from high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS) subjects. Machine learning was used for handling imbalanced data and feature selection before differential expression analysis to identify significantly dysregul

SUBMITTER: Suvanasuthi R 

PROVIDER: S-EPMC11696073 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature