Cuproptosis related lncRNA signature as a prognostic and therapeutic biomarker in osteosarcoma immunity.

ABSTRACT: Osteosarcoma is one of the most common malignant bone tumours in children. In this study, we aimed to construct a cuproptosis-related lncRNAs signature to predict the prognosis and immune landscape of osteosarcoma patients. Databases from TARGET were used to acquire osteosarcoma patient datasets, which included clinical information and RNA sequencing data. Cuproptosis-related lncRNAs was obtained by correlation analysis. Through univariate Cox regression analysis, prognosis-related lncRNAs were obtained. We used nonnegative matrix factorization clustering to identify potential molecular subgroups with different cuproptosis-related lncRNA expression patterns. The least absolute shrinkage and selection operator algorithm and multivariate Cox regression analysis were used to construct the pro

SUBMITTER: Gao Z 

PROVIDER: S-EPMC11696132 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature