Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation.

ABSTRACT: This study compared the degree of secondary hyperalgesia and somatosensory threshold changes induced by topical capsaicin between spinal and trigeminal innervation. This crossover clinical trial included 40 healthy individuals in which 0.25 g of 1% capsaicin cream was randomly applied for 45 minutes to a circular area of 2 cm² to the skin covering the masseter muscle and forearm in 2 different sessions, separated by at least 24 hours and no more than 72 hours (washout period). The main outcome variables were the area of allodynia and pinprick hyperalgesia, as well as electrical and mechanical pain thresholds within the area of pinprick hyperalgesia. Mixed ANOVA models and McNemar tests were applied to the data (p = 0.050). The occurrence of allodynia and pinprick hyperalgesia wa

SUBMITTER: Novaes IC 

PROVIDER: S-EPMC11696148 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature