Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease.

ABSTRACT: The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiography (ICG) and echocardiographic parameters reflecting left ventricular function in 54 patients newly diagnosed with CD. The parameters assessed via ICG included stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), systemic vascular resistance index (SVRI), total artery compliance index (TACI). The echocardiographic parameters included left ventricular mass index (LVMI) and left ventricular systolic and diastolic parameters. Higher LVMI values were associated with

SUBMITTER: Wlochacz A 

PROVIDER: S-EPMC11696225 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature