VTA projections to M1 are essential for reorganization of layer 2-3 network dynamics underlying motor learning.

ABSTRACT: The primary motor cortex (M1) is crucial for motor skill learning. Previous studies demonstrated that skill acquisition requires dopaminergic VTA (ventral-tegmental area) signaling in M1, however little is known regarding the effect of these inputs at the neuronal and network levels. Using dexterity task, calcium imaging, chemogenetic inhibiting, and geometric data analysis, we demonstrate VTA-dependent reorganization of M1 layer 2-3 during motor learning. While average activity and average functional connectivity of layer 2-3 network remain stable during learning, activity kinetics, correlational configuration of functional connectivity, and average connectivity strength of layer 2-3 neurons gradually transform towards an expert configuration. Additionally, sensory tone representation gra

SUBMITTER: Ghanayim A 

PROVIDER: S-EPMC11696230 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature