Integrative multi-omics analysis reveals the role of toll-like receptor signaling in pancreatic cancer.

ABSTRACT: As one of the most destructive and invasive cancers, pancreatic cancer exhibits complex tumor heterogeneity, which has been a major challenge for clinicians in terms of patient treatment and prognosis. The toll-like receptor (TLR) pathway is closely related to the immune microenvironment within various cancer tissues. To explore the development pattern of pancreatic cancer and find an ideal biomarker, our research has explored the mechanism of the TLR pathway in pancreatic cancer. We collected single-cell expression data from 57,024 cells and transcriptomic data from 945 pancreatic cancer patients, and conducted a series of analyses at both the single-cell and transcriptomic levels. By calculating the TLR pathway score, we clustered pancreatic cancer patients and conducted a series of anal

SUBMITTER: Peng J 

PROVIDER: S-EPMC11696379 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature