Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder.

ABSTRACT: Developmental language disorder (DLD) is a neurodevelopmental disorder involving impaired language abilities. Its genetic etiology is heterogeneous, involving rare variations in multiple susceptibility loci. However, family-based studies on gene mutations are scarce. We performed whole-exome sequencing (WES) of a first-time-described Tunisian-family with DLD. Analyses of segregation patterns with stringent filtering of the exome data identified disease-causing compound heterozygous variants. In the MRNIP gene, two variants were detected including a synonymous low-frequency variant c.345G > C and a nonsense rare variant c.112G > A predicted pathogenic. In the ABHD14A gene, four variants were identified including a rare missense variant c.689T > G and three splice-site variants c.70-8C > T,

SUBMITTER: Bouzid A 

PROVIDER: S-EPMC11696457 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature