A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies.

ABSTRACT: This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable of performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in a murine brain. We have termed it the All-in-One FUS system for murine brain studies, which is the first FUS system of its kind. The 1.5 MHz ultrasound transducer was fabricated and driven using a custom electronic driver to produce 3-cycle pulses with a focal peak-negative pressure (P-) of up to 87 MPa at a low duty cycle (< 0.1%) for histotripsy as well as 50% duty cycle pulsed-ultrasound with a spatial-peak temporal-average intensity (I_spta) of up to 251 W/cm² for the other FUS modalities.

SUBMITTER: Kaovasia TP 

PROVIDER: S-EPMC11696467 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature