Piperine-loaded mesoporous silica nanoparticles as a promising strategy for targeting Echinococcus granulosus protoscoleces.

ABSTRACT: Medical and surgical treatments for cystic echinococcosis (CE) are challenged by various complications. This study evaluates in vitro protoscolicidal activity of piperine-loaded mesoporous silica nanoparticles (PIP-MSNs) against protoscoleces of Echinococcus granulosus. MSNs were prepared by adding tetraethyl orthosilicate to cetyltrimethylammonium bromide and NaOH, and then loaded with PIP. The mean particle size and hydrodynamic diameter of MSNs were determined at 68 ± 4.5 and 101.4 ± 50.4 nm using transmission electron microscopy and dynamic light scattering, respectively. X-ray diffraction, Fourier-transform infrared analysis, and UV-spectrophotometry confirmed drug loading. Drug loading efficiency and drug loading capacity were calculated at 60% and 18%, respectively. The drug release

SUBMITTER: Sahebi K 

PROVIDER: S-EPMC11696618 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature