DRED: A Comprehensive Database of Genes Related to Repeat Expansion Diseases.

ABSTRACT: Expansion of tandem repeats in genes often causes severe diseases, such as fragile X syndrome, Huntington's disease, and spinocerebellar ataxia. However, information on genes associated with repeat expansion diseases is scattered throughout the literature, systematic prediction of potential genes that may cause diseases via repeat expansion is also lacking. Here, we develop DRED, a Database of genes related to Repeat Expansion Diseases, as a manually-curated database that covers all known 61 genes related to repeat expansion diseases reported in PubMed and OMIM, along with the detailed repeat information for each gene. DRED also includes 516 genes with the potential to cause diseases via repeat expansion, which were predicted based on their repeat composition, genetic variations, genomic f

SUBMITTER: Shi Q 

PROVIDER: S-EPMC11696699 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature