MitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism.

ABSTRACT:

Motivation

Mitochondria are essential for cellular metabolism and are inherently flexible to allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial metabolism affects different tissues in different ways leading to challenges in understanding the pathology of mitochondrial diseases. System-level metabolic modelling is useful in studying tissue-specific mitochondrial metabolism, yet despite the mouse being a common model organism in research, no mouse specific mitochondrial metabolic model is currently available.

Results

Building upon the similarity between human and mouse mitochondrial metabolism, we present mitoMammal, a genome-scale metabolic model that contains human and mouse specific gene-product reaction rules. MitoMammal is able to

SUBMITTER: Chapman S 

PROVIDER: S-EPMC11696703 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature