Ferrocenyl-Substituted Curcumin Derivatives as Potential SHP-2 Inhibitors for Anticolorectal Cancer: Design, Synthesis and In Vitro Evaluation.

ABSTRACT: A panel of ferrocenyl-substituted curcumin derivatives has been designed and synthesized as protein tyrosine phosphatase proto-oncogene SHP-2 inhibitors. Antiproliferative activities of the synthesized compounds were tested against colorectal cancer cell lines (including RKO, SW480, and CT26). Compound 3f showed excellent activities against the tested cell lines with IC₅₀ values of 5.72, 3.71, and 1.42 μM. The cytotoxicity of compound 3f was investigated on human normal colon epithelial cell line NCM460 with IC₅₀ values of 929 μM compared to curcumin with IC₅₀ values of 431 μM. The Western blot analysis approved that the expression level of SHP-2 in the CT26 and SW480 cell lines after being treated with 3f was decreased, meanwhile it al

SUBMITTER: Zhang XZ 

PROVIDER: S-EPMC11696753 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature