The zinc finger protein560(ZNF560) functions as a novel oncogenic gene in osteosarcoma.

ABSTRACT:

Background

Abnormal expression of Zinc finger (ZNF) genes is commonly observed in osteosarcoma (OS), the most prevalent malignant bone tumor in children and teenagers. This project focused on the role of ZNF560 in the progress of OS.

Methods

The published datasets including TCGA-SARC and GSE99671 was utilized to screen out the abnormal expression of ZNF560 and associated gene patterns in sarcoma and OS tissues. Prognosis value of ZNF560 was identified in TCGA-SARC and OS cohorts. In order to manipulate ZNF560 expression in HOS and MG63 osteosarcoma (OS) cells, genetic strategies such as shRNA constructs were utilized. The expression patterns of ZNF560 were analyzed through techniques such as immunohistochemistry, Western blotting, and qRT-PCR.

Results

By analyzing dat

SUBMITTER: Dong X 

PROVIDER: S-EPMC11696763 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature