Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between PolyP and the activity of AMPK.

ABSTRACT: Inorganic polyphosphate (polyP) is an evolutionary and ancient polymer composed by orthophosphate units linked by phosphoanhydride bonds. In mammalian cells, polyP shows a high localization in mammalian mitochondria, and its regulatory role in various aspects of bioenergetics has already been demonstrated, via molecular mechanism(s) yet to be fully elucidated. In recent years, a role for polyP in signal transduction, from brain physiology to the bloodstream, has also emerged.

Objective

In this manuscript, we explored the intriguing possibility that the effects of polyP on signal transduction could be mechanistically linked to those exerted on bioenergetics.

Methods

To conduct our studies, we used a combination of cellular and animal models.

Results

Our findings demonst

SUBMITTER: Da Costa RT 

PROVIDER: S-EPMC11696858 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature