Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds.

ABSTRACT: Herein, we present an efficient and practical method for multicomponent carbo-heterofunctionalization of alkenes via radical-polar crossover photoredox catalysis. Employing geminal bromonitroalkanes as redox-active reagents with a wide range of O-centered nucleophiles allows rapid access to various 1,3-difunctionalized nitro compounds, including β-nitro ketones, 1,3-nitro alcohols, 1,3-nitro ethers as well as cyclic molecules.

SUBMITTER: Patra S 

PROVIDER: S-EPMC11696862 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature