Asymmetric distribution of G-quadruplex forming sequences in genomes of retroviruses.

ABSTRACT: Retroviruses are among the most extensively studied viral families, both historically and in contemporary research. They are primarily investigated in the fields of viral oncogenesis, reverse transcription mechanisms, and other infection-specific aspects. These include the integration of endogenous retroviruses (ERVs) into host genomes, a process widely utilized in genetic engineering, and the ongoing search for HIV/AIDS treatment. G-quadruplexes (G4) have emerged as potential therapeutic targets in antiviral therapy and have been identified in important regulatory regions of viral genomes. In this study, we examine the presence of potential G-quadruplex-forming sequences (PQS) across all currently available unique retroviral genomes. Given that these retroviral genomes typically consist o

SUBMITTER: Kledus F 

PROVIDER: S-EPMC11696869 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature