Biotene Versus HydraSmile for Radiation-Induced Xerostomia: Randomized Double-Blind Cross-Over Study.

ABSTRACT:

Objective

This study aims to compare the effectiveness of 2 artificial saliva substitutes (Biotène vs HydraSmile) in the symptomatic management of radiation-induced xerostomia.

Study design

Randomized double-blind cross-over study.

Setting

Single tertiary care academic institution.

Methods

Included adult patients ≥ 6 months postradiotherapy (50-70 gy) for squamous cell carcinoma of the oral cavity, oropharynx, or larynx. The primary endpoint was change in overall subjective xerostomia score from baseline, through use of HydraSmile versus Biotène. Scores were derived from a 100-point visual analog scale, with higher scores indicating better symptomatic control. Analysis of covariance model was used to regress the difference in after-treatment measurement between

SUBMITTER: Harley RJ 

PROVIDER: S-EPMC11696889 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature