Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors.

ABSTRACT: Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds of effector proteins inside eukaryotic cells to ensure intracellular replication. Our understanding of the molecular functions of the largest pathogenic arsenal known to the bacterial world remains incomplete. By leveraging advancements in 3D protein structure prediction, we provide a comprehensive structural analysis of 368 L. pneumophila effectors, representing a global atlas of predicted functional domains summarized in a database ( https://pathogens3d.org/legionella-pneumophila ). Our analysis identified 157 types of diverse functional domains in 287 effectors, including 159 effectors with no prior functional annotations. Furthermore, we identified 35 cryptic domains in 30 effector models that hav

SUBMITTER: Patel DT 

PROVIDER: S-EPMC11696984 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature