Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks.

ABSTRACT: The ovary is the main controller of female fertility, unfortunately, its onset of aging processes was earlier than other organs. Our previous studies showed calcium (Ca) deficiency reduced ovarian weight and declined numbers of dominant follicles in an avian model. However, whether Ca provided a functional role in follicle development of aged avian, and its further mechanism was still unknown. In this study, fifty180-day-old and fifty 700-day-old female Longyan ducks were divided into the young group and the aged group to illustrate the differences of Ca signaling and further mechanisms. We found the poor productive performance of aged ducks was correlated with follicle decreased numbers and atrophied microstructure, and restricted antioxidant ability of granulosa cells (GCs). Then, accord

SUBMITTER: Jin CL 

PROVIDER: S-EPMC11697049 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature