Ultrasonic optic nerve sheath diameter as a new predictor for the mortality of patients with large hemispheric infarction.

ABSTRACT: Large hemispheric infarction (LHI) is a severe form of stroke with high mortality and poor outcomes. Ultrasonic optic nerve sheath diameter (ONSD) is considered an effective indicator for intracranial hypertension. Our study aimed to validate the efficiency of ultrasonic ONSD and develop a nomogram to identify LHI patients who have 90-day mortality. We recruited 419 LHI patients (training cohort, n = 202; internal validation cohort, n = 86; and external validation cohort, n = 131) from six centers. Demographic, laboratory, computed tomography, and ultrasonic data were collected. At 90 days, 41.8% of patients died. Ultrasonic ONSD (odds ratio [OR], 7.026; 95% CI, 2.638-18.708; P < 0.001), male (OR, 8.620; 95% CI, 2.962-25.092; P < 0.001), midline shift (OR, 1.207; 95% CI, 1.085-1.342; P = 0

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11697081 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature