Sex differences in the pharmacokinetics of anticancer drugs: a systematic review.

ABSTRACT:

Background

In addition to the effect of body weight, a patient's sex can influence the pharmacokinetics (PK) of anticancer agents, and thereby their activity and safety. The magnitude and relevance of sex differences, however, are currently unclear.

Methods

We carried out a systematic review of published studies (clinical, n ≥ 10) on Food and Drug Administration (FDA)-approved (on 31 January 2022) anticancer drugs (excluding hormonal agents), aiming to identify significant PK differences between male and female patients. A difference of ≥20% on PK parameters (clearance or trough concentration) was considered significant. The methodological quality was assessed using the National Institutes of Health study quality assessment tool. This systematic review was conducted accordin

SUBMITTER: Delahousse J 

PROVIDER: S-EPMC11697095 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature