Diagnostic Impact of FISHseq as a New Pathologic Criterion for Endocarditis According to the Duke Criteria.

ABSTRACT:

Background

For clinicians treating patients with infective endocarditis (IE), identifying the causative microorganisms poses a critical diagnostic challenge. Standard techniques including blood and heart valve cultures often yield inconclusive results. According to the recent 2023 Duke-ISCVID Criteria, molecular methods represent potent tools to enhance this aspect of IE diagnostics and guide subsequent therapeutic strategies.

Methods

We retrospectively analyzed data from 124 consecutive patients who underwent heart valve surgery due to suspected IE at München Klinik Bogenhausen. The standard diagnostic pathway, which included blood culture, valve culture, histopathological analysis, and polymerase chain reaction (PCR)/sequencing, was compared with the enhanced diagno

SUBMITTER: Hopf AGM 

PROVIDER: S-EPMC11697105 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature