Causal relationships between air pollution and common autoimmune diseases: a two-sample Mendelian randomization study.

ABSTRACT: Air pollution is strongly associated with autoimmune diseases (ADs), however, the genetic causality between them remains poorly understood. Therefore, the aim of this study is to determine the relationship between common air pollutants and ADs through Mendelian randomization (MR) analysis. We conducted a MR study using aggregated data from publicly available genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) associated with 5 common air pollutants are used as instrumental variables. Random-effects inverse variance weighted (IVW) is used as the primary method to assess causal relationships, with results reported in terms of odds ratios (OR). In addition, we used a two-step MR to assess the mediating role of common risk factors for ADs in the effects of air pollut

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11697238 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature