Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin.

ABSTRACT: The eukaryotic cytoskeleton is an intricate network of three types of mechanically distinct biopolymers - actin filaments, microtubules and intermediate filaments (IFs). These filamentous networks determine essential cellular functions and properties. Among them, microtubules are important for intracellular transport and establishing cell polarity during migration. Despite their intrinsic stiffness, they exhibit characteristic bending and buckling in cells due to nonthermal forces acting on them. Interactions between cytoskeletal filaments have been found but are complex and diverse with respect to their effect on the mechanical behavior of the filaments and the architecture of networks. We systematically study how actin and vimentin IFs influence the network structure and local bending of

SUBMITTER: Blob A 

PROVIDER: S-EPMC11697242 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature