Correlation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues.

ABSTRACT: Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development and progression of many ailments, such as aging, cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, cancer, preeclampsia or multiple sclerosis. While phenols and polyphenols are the most studied antioxidants structurally similar compounds such as anilines or thiophenols are sporadically analyzed despite their radical scavenging potential. This work assesses the impact of structural features of phenols and thiophenols on their antioxidant activity. Seventeen pairs of phenol/thiophenol analogues, possessing both electron-donating and withdrawing groups were selected for this study. Several physicochemical properties of the compoun

SUBMITTER: Vlocsko RB 

PROVIDER: S-EPMC11697322 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature