A Ventilated Three-Dimensional Artificial Lung System for Human Inhalation Exposure Studies.

ABSTRACT: Traditional in vitro and in vivo models for inhalation toxicology studies often fail to replicate the anatomical and physiological conditions of the human lung. This limitation hinders our understanding of intrapulmonary exposures and their related health effects. To address this gap, we developed a ventilated artificial lung system that replicates human inhalation exposures in four key aspects: (1) facilitating continuous breathing with adjustable respiratory parameters; (2) distributing inhaled aerosols through transitional airflow fields in 3D-printed airway structures, which enables size-dependent particle deposition; (3) duplicating the warm and humid lung environment to promote inhaled aerosol dynamics, such as hygroscopic growth; and (4) supporting the cultivation of human airway ep

SUBMITTER: Chen H 

PROVIDER: S-EPMC11697334 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature