Unknown

Dataset Information

0

Binding of <i>cis</i>-[Ru(phen)<sub>2</sub>(3,4Apy)<sub>2</sub>]<sup>2+</sup> to Model Lipid Membranes: Implications for New Tools in the Development of Antiamyloid Drugs.

ABSTRACT: This study explores the interactions of the cis-[Ru(phen)2(Apy)2]2+ complex (RuApy, phen = 1,10-phenanthroline, Apy = 3,4-aminopyridine) with model lipid membranes to explain the role this complex plays in mitigating Aβ toxicity in PC12 neuronal cells. Fluorescence quenching, surface pressure isotherms in Langmuir monolayers, and infrared reflection-absorption analyses revealed that the positively charged RuApy interacts with the phosphate headgroups of monolayers, indirectly affecting ester carbonyl groups through hydrogen bonding with the amino group of the pyridine ligand of RuApy. These results offer a scenario for the protective effect of RuApy against Aβ toxicity in neuronal cells in which these interactions shield the electrostatic interactions of Aβ with lipid membranes, preserving membrane integrity and mitigating the deleterious influence of Aβ. This opens new avenues for antiamyloid strategies, focusing on compounds that prevent salt-bridge formation between bilayer membranes and amyloid proteins, aiding in the rational design of effective antiamyloid agents for therapeutic application.

SUBMITTER: da Cruz Garcia ML 

PROVIDER: S-EPMC11697347 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Binding of &lt;i&gt;cis&lt;/i&gt;-[Ru(phen)&lt;sub&gt;2&lt;/sub&gt;(3,4Apy)&lt;sub&gt;2&lt;/sub&gt;]&lt;sup&gt;2+&lt;/sup&gt; to Model Lipid Membranes: Implications for New Tools in the Development of Antiamyloid Drugs.

da Cruz Garcia Maria Laura ML   Paixão Rafaela Ribeiro RR   Pazin Wallance M WM   Oliveira Osvaldo N ON   Cremer Paul S PS   Carlos Rose Maria RM  

Langmuir : the ACS journal of surfaces and colloids 20241216 52

This study explores the interactions of the <i>cis</i>-[Ru(phen)<sub>2</sub>(Apy)<sub>2</sub>]<sup>2+</sup> complex (RuApy, phen = 1,10-phenanthroline, Apy = 3,4-aminopyridine) with model lipid membranes to explain the role this complex plays in mitigating Aβ toxicity in PC12 neuronal cells. Fluorescence quenching, surface pressure isotherms in Langmuir monolayers, and infrared reflection-absorption analyses revealed that the positively charged RuApy interacts with the phosphate headgroups of mo  ...[more]

Similar Datasets

Unknown Hierarchical Ru&lt;sup&gt;0&lt;/sup&gt;/Ru&lt;sup&gt;δ+&lt;/sup&gt;/Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt; electrocatalyst enabling phenolic contaminant-to-chemical conversion.
| S-EPMC12644744 | biostudies-literature
Unknown Isolation and characterization of the dimetal decacarbonyl dication [Ru&lt;sub&gt;2&lt;/sub&gt;(CO)&lt;sub&gt;10&lt;/sub&gt;]&lt;sup&gt;2+&lt;/sup&gt; and the metal-only Lewis-pair [Ag{Ru(CO)&lt;sub&gt;5&lt;/sub&gt;}&lt;sub&gt;2&lt;/sub&gt;]&lt;sup&gt;+&lt;/sup&gt; .
| S-EPMC11640294 | biostudies-literature
Unknown Highly Efficient Removal of Organic Pollutants with HCO&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;-&lt;/sup&gt;-Enhanced Ru(III)/NaClO Process.
| S-EPMC11765646 | biostudies-literature
Unknown Mg&lt;sub&gt;44.29&lt;/sub&gt;Ru&lt;sub&gt;7&lt;/sub&gt;.
| S-EPMC12412686 | biostudies-literature
Unknown Dimers of D76N-β&lt;sub&gt;2&lt;/sub&gt;-microglobulin display potent antiamyloid aggregation activity.
| S-EPMC9712992 | biostudies-literature
Unknown Kitaev interactions through extended superexchange pathways in the j eff = 1 / 2 Ru&lt;sup&gt;3+&lt;/sup&gt; honeycomb magnet RuP&lt;sub&gt;3&lt;/sub&gt;SiO&lt;sub&gt;11&lt;/sub&gt;.
| S-EPMC11568271 | biostudies-literature
Unknown Ringing the Changes: Effects of Heterocyclic Ring Size on Stereoselectivity in [(η&lt;sup&gt;5&lt;/sup&gt;-C&lt;sub&gt;5&lt;/sub&gt;Me&lt;sub&gt;5&lt;/sub&gt;)RhCl], [(η&lt;sup&gt;5&lt;/sup&gt;-C&lt;sub&gt;5&lt;/sub&gt;Me&lt;sub&gt;5&lt;/sub&gt;)IrCl] and [Ru(η&lt;sup&gt;6&lt;/sup&gt;-cymene)Cl] Complexes of Chiral 3-Amino-1-Azacycles.
| S-EPMC11478173 | biostudies-literature
Unknown Precision-Engineered Co-N&lt;sub&gt;4-&lt;i&gt;x&lt;/i&gt;&lt;/sub&gt; -C &lt;i&gt;&lt;sub&gt;x&lt;/sub&gt;&lt;/i&gt; Single Atoms Enhance Potential-Resolved Ru(bpy)&lt;sub&gt;3&lt;/sub&gt; &lt;sup&gt;2+&lt;/sup&gt; Electrochemiluminescence via Reactive Oxygen Species.
| S-EPMC12351920 | biostudies-literature
Unknown Stereoselective self-assembly of cis- and trans- [Pt&lt;sub&gt;2&lt;/sub&gt;L&lt;sub&gt;2&lt;/sub&gt;] metallacycles via geometrically-asymmetric 90&lt;sup&gt;o&lt;/sup&gt; Pt(II) acceptors.
| S-EPMC12748632 | biostudies-literature
Unknown Mn&lt;sup&gt;2+&lt;/sup&gt; and [Ru(bpy)&lt;sub&gt;3&lt;/sub&gt;]&lt;sup&gt;2+&lt;/sup&gt; in UiO-67 metal organic frameworks enhance photocatalytic oxidation of benzylamine &lt;i&gt;via&lt;/i&gt; an electron transfer pathway.
| S-EPMC12517270 | biostudies-literature