Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals.

ABSTRACT: Rising cases of type 2 diabetes (T2D) in India, especially in metropolitan cities is an increasing concern. The individuals that were most affected are young professionals working in the corporate sector. However, the corporate sector has remained the least explored for T2D risk predisposition. Considering corporate employees' lifestyles and the role of gene-environment interaction in T2D susceptibility, the study aims to find genetic variants associated with T2D predisposition. In this first kind of study, 680 young professionals (284 T2D cases, and 396 controls) were diagnosed and screened for 2658 variants on an array designed explicitly for the CoGsI study. The variant filtering was done at Bonferroni p-value of 0.000028. The genetic data was analysed using PLINK v1.09, SPSS, R program

SUBMITTER: Husami SF 

PROVIDER: S-EPMC11697386 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature