Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation.

ABSTRACT:

Background

The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer from an immunological perspective, along with elucidating the underlying mechanism. Additionally, we aimed to identify the clinical potential of combining epigenetic inhibitors with immune checkpoint inhibitors to improve the efficacy of immunotherapy for gastric cancer.

Methods

The correlation between ARID1A gene expression and gastric cancer patient survival was analyzed using the GEO dataset GSE62254. The association between chemokines (CXCL9, CXCL10) and ARID1A was conducted using GSE15460 dataset. Real-time PCR was employed for gene expression analysis, while chromatin immunoprecipitation was used to identify transcriptional regulation on t

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11697466 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature