Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications.

ABSTRACT: Epigenetic modifications have been identified as critical molecular determinants influencing macrophage plasticity and heterogeneity. Among these, histone lactylation is a recently discovered epigenetic modification. Research examining the effects of histone lactylation on macrophage activation and polarization has grown substantially in recent years. Evidence increasingly suggests that lactate-mediated changes in histone lactylation levels within macrophages can modulate gene transcription, thereby contributing to the pathogenesis of various diseases. This review provides a comprehensive analysis of the role of histone lactylation in macrophage activation, exploring its discovery, effects, and association with macrophage diversity and phenotypic variability. Moreover, it highlights the im

SUBMITTER: Bao C 

PROVIDER: S-EPMC11697715 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature