Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.

ABSTRACT:

Background

The oral cavity is a complex environment which harbours the second largest and most diverse microflora after the gastrointestinal tract. The bacteriome in the oral cavity plays a pivotal role in promoting the health and well-being of human beings. Gingivitis, an inflammation of the gingival tissue, arises due to plaque accumulation on the teeth, often leads to periodontitis. Progression of periodontitis resulting in clinical attachment loss, bone loss and eventually the tooth loss is poorly understood. The present study explores the transitions in microbioata, oxidative stress and polyamine levels during the disease evolution which can contribute to developing effective therapeutic approaches.

Methods

Saliva samples were collected from seventy-two individuals afte

SUBMITTER: Rashid MH 

PROVIDER: S-EPMC11697722 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature