Bioinformatics analysis of miR-2861 and miR-5011-5p that function as potential tumor suppressors in colorectal carcinogenesis.

ABSTRACT:

Background

The study aimed to was to investigate the relationship between miR-2861, miR-5011-5p, and colorectal carcinogenesis.

Method

In the present study, it was isolated RNA from both the tumor and non-tumor tissue of a total of 80 CRC patients and after synthesizing the cDNA, it was performed qRT-PCR to determine the expression levels of miR‑2861 and miR‑5011-5p. In addition, it was predicted that dysregulated miRNAs targets, pathways and functional gene annotations that may be important in colorectal carcinogenesis using KEGG pathway and GO analysis.

Results

The resulting data revealed that both expression levels of miR-2861 and miR-5011-5p were significantly decreased in tumor tissues compared with non-tumor tissues of CRC patients. The GO and KEGG pathway analy

SUBMITTER: Aytekin A 

PROVIDER: S-EPMC11697744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature