The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution.

ABSTRACT:

Background

The advent of next generation sequencing technologies has enabled a surge in the number of whole genome sequences in public databases, and our understanding of the composition and evolution of bacterial genomes. Besides model organisms and pathogens, some attention has been dedicated to industrial bacteria, notably members of the Lactobacillaceae family that are commonly studied and formulated as probiotic bacteria. Of particular interest is Lactobacillus acidophilus NCFM, an extensively studied strain that has been widely commercialized for decades and is being used for the delivery of vaccines and therapeutics.

Results

Here, we revisit the L. acidophilus genome, which was sequenced twenty years ago, and determined the core and pan genomes of 114 publicly availab

SUBMITTER: Pan M 

PROVIDER: S-EPMC11697832 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature