Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis.

ABSTRACT: Endometriosis is a complex gynecological condition characterized by abnormal immune responses. This study aims to explore the immunomodulatory effects of monoterpene glycosides from Paeonia lactiflora on endometriosis. Using the ssGSEA algorithm, we assessed immune cell infiltration levels between normal and endometriosis groups. Key targets were identified through differential expression analysis of the GSE51981 dataset. Potential immunomodulatory targets of Paeonia lactiflora compounds were identified through Venn diagram analysis, followed by enrichment and machine learning analyses. A nomogram was developed for predicting endometriosis, while molecular docking explored compound-target interactions. Significant differences in immune cell infiltration were observed, with increased CD8 T

SUBMITTER: Zhan J 

PROVIDER: S-EPMC11697917 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature