Hydroxychloroquine enhances insulin sensitivity and ameliorates abnormal lipid metabolism in obese women with polycystic ovary syndrome.

ABSTRACT:

Background

Hydroxychloroquine (HCQ) is frequently utilized in rheumatic immune disorders and has been discovered to exert hypoglycemic effects in some obese women with polycystic ovary syndrome(PCOS), however, the precise efficacy and mechanism of action remain ambiguous.

Objective

To examine the impact of HCQ on glucose and lipid metabolism as well as sex hormone levels in obese women with PCOS.

Method

Fifty obese women with PCOS were randomly allocated into two groups: HCQ group (n = 25) and metformin (MET) group (n = 25). The HCQ group received a daily dose of 200 mg hydroxychloroquine, while the MET group received a daily dose of 1000 mg metformin. Body fat parameters, glucose and lipid metabolism levels, as well as hormone levels were evaluated. Additionally, the

SUBMITTER: Wang R 

PROVIDER: S-EPMC11697925 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature