Seizure aggravation by ampicillin/sulbactam in an elderly patient with status epilepticus.

ABSTRACT:

Background

Ampicillin/sulbactam (ABPC/ SBT) is one of the most common β-lactam antibiotics for patients with status epilepticus complicated with aspiration pneumonia. It is known that β-lactam antibiotics such as penicillin aggravate epileptic seizures or status epilepticus. Here, we investigated whether ABPC/SBT aggravates seizures using electroencephalography (EEG) monitoring.

Case presentation

An 84-year-old male with status epilepticus who presented with a new onset of clonic seizures mainly of his left side and underwent continuous video EEG was analyzed. He had been suffering from severe ulcerative colitis and infectious enteritis, delirium, atrial fibrillation and deep venous thrombosis. His cerebrospinal fluid analysis was unremarkable. Four days after starting levet

SUBMITTER: Obata K 

PROVIDER: S-EPMC11697952 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature