Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum.

ABSTRACT: Glutathione reductase (GR) plays a pivotal role in managing oxidative stress, a process crucial for microbial virulence and adaptation, yet it has not been extensively explored in bacteria such as Avibacterium paragallinarum (Av. paragallinarum). This study examined the specific roles of GR in Av. paragallinarum, focusing on how GR modulates the bacterium's response to oxidative stress and impacts its pathogenic behavior. Using gene knockouts together with transcriptomic and metabolomic profiling, we identified an important shift in redox balance due to GR deficiency, which disrupted energy metabolism and weakened the oxidative stress defense, culminating in a notable decline in virulence. In addition, decreased growth rates, reduced biofilm production, and weakened macrophage interactions

SUBMITTER: Zhi Y 

PROVIDER: S-EPMC11697956 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature